المناهج الدراسية

Number of

Lectures

Subject

1

Introduction

-De Definition & branches of  pathology

Causes and etiology of diseases

Pathogenesis and nature of diseases

Morphological changes of disease                                                       Prognosis and complications

4

Cell injury, cell death and Adaptations

Overview of cellular response to stress & noxious stimuli

Cellular adaptations to stress.

-Hypertrophy

-Hyperplasia

-Atrophy

-Metaplasia

Causes of cell injury

The morphology of cell and tissue injury

-Reversible injury

-Necrosis

-Patterns of tissue necrosis

-Subcellular responses to injury

Mechanisms of cell injury

Examples of irreversible cell injury and necrosis

-Coagulative necrosis

-Caseous necrosis

-Liquefactive necrosis

-Fatty necrosis

-Fibrinoid necrosis

-Gangrenous necrosis

Apoptosis

Intracellular accumulations

-Fatty change

-Pigmentation (Exogenous and endogenous)

-Pathological calcification

6

Acute And Chronic Inflammation

Overview of Inflammation

- Definition

- Causes

Types:

-Acute Inflammation

-Vascular changes

-Change in vascular blood flow & caliber

-Increased vascular permeability

-Leukocytes cellular events

-Leukocyte recruitment

-Margination and rolling

-Adhesion and transmigrations

-Chemotaxis

-Leukocytes activation

-Phagocytosis

-Killing and degradation of microbes

-Outcomes of Acute Inflammation

-Morphological patterns of acute Inflammation

-Serous Inflammation

-Fibrinous Inflammation

-Suppurative (purulent) Inflammation

-Catarrhal inflammation

-Ulceration

-Gangrenous Inflammation

-Pseudomembranous Inflammation

-Chemical Mediators

-Cell – derived mediators

-Plasma protein – derived mediators

-Chronic Inflammation

-Chronic inflammatory cells and mediators

-Granulomatous inflammation

-Morphological pattern of chronic  inflammation

Systemic effects of Inflammation

2

Tissue Repair: Regeneration, Healing and Fibrosis

Overview of tissue repair.

-Regeneration

-The control of cell proliferation

-The cell cycle

-Proliferative capacities of tissues

-Growth factors

-Extracellular matrix (ECM) and cell-matrix                                            interactions

-Roles of extracellular matrix.

-Components of extracellular Matrix

-Repair by connective tissue

-Angiogenesis

-Migration of fibroblasts and ECM deposition

(Scar  formation)

-ECM and Tissue Remodeling

Cutaneous wound healing

-Healing by first intention

-Healing by second  intention

-Wound strength

Pathologic Aspects of Repair

Factors Affecting Wound Healing

-Local Factors

-Systemic Factors

8

Microbial Infections

Introduction to microbial infections

Non-specific defense mechanisms

Categories of infectious agents

Routes of infections

How microorganism can cause disease.

Viral infections

-Introduction

-Mechanisms of viral injury at cellular level.

-Transient viral infection

-Latent viral infection

-Slow viral infection

-H1N1 viral infection

Bacterial infections

-Pathogenesis of bacterial infections

-Acute bacterial infections

-Acute bacterial infections general types

-Common pyogenic bacteria

-Gangrene

Definition and types

-Chronic bacterial  infections

- Mycobacterium tuberculosis

-Leprosy

-Syphilis

-Fungal infections